Prasad

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Curriculum Vitae

• Professor



Department of Chemical Engineering
University of Delaware
Newark, Delaware 19716

302-831-2879
302-831-1048 fax

dhurjati@che.udel.edu


" Our current research in “Biosystems Modeling and Bioinformatics” is built on two decades of accomplishments in biotechnology and the application of knowledge-based expert systems for process fault diagnosis. In biotechnology, our research has resulted in a better understanding of microscopic and macroscopic variables that influence the kinetics of genetically engineered microorganisms. We have investigated different promoters, specialized ribosome systems, microbial hosts, and bioreactor conditions, for the improved production of active proteins. We have collaborated with the Pasteur Institute in Paris to examine the effects of gene sequence on inclusion body formation and also collaborated with DuPont to construct genetically engineered cells that emit light when exposed to pollutants. A second area of major research contributions is in the application of knowledge-based expert systems for on-line fault diagnosis. In a joint project with Foxboro and DuPont, our research group pioneered the first industrial application of an expert system (FALCON), for fault diagnosis in a commercial-scale process. Dynamic simulations and the integration of qualitative domain knowledge with quantitative knowledge from mathematical models were central to this project. A common underlying theme in our work in both biotechnology and fault diagnosis has been the use of dynamic mathematical models, qualitative and quantitative domain knowledge, and artificial intelligence approaches for data interpretation and knowledge integration. The introduction of a gene into an organism perturbs it at many levels of cellular hierarchy. Genomic, Transcriptomic, Proteomic and Metabolic data provide insight into the regulatory and metabolic effects of such gene manipulations at the whole cell level. Our current research combines modeling approaches with knowledge-based data analysis strategies to convert the massive amounts of such bioinformatic data into knowledge. "

Education

Honors and Awards

  • 1986-1991, NSF Presidential Young Investigator Award

Patents


    Fellowships and Memberships

    • American Institute of Chemical Engineers - Member
    • American Chemical Society - Member
    • International Society of Computational Biology - Member
    • American Institute for Medical and Biological Engineers - Member


    Lectures

    • D. J. Michaud, A. N. Beris, P. S. Dhurjati, Robust Design Optimization of a Batch Composite Process Using Evolutionary Strategies, November 1999, AIChE Annual Meeting, Dallas, TX

    • D. J. Michaud, A. N. Beris, P. S. Dhurjati, System Analysis and Processing of Thick-Sectioned Vinyl Ester Composite Systems, November 1999, AIChE Annual Meeting, Dallas, TX

    • Biotechnology for Dummies, Feb 3, 1999, Mechanical Engineering Department, University of Delaware, Newark, DE

    • Bioinformatics, Feb 12, 1999, Electrical Engineering Department, University of Delaware, Newark, DE

    • Biotechnology, Feb 19, 1999, College of Business and Economics, University of Delaware, Newark, DE

    • Bioinformatics, Feb 26, 1999, CAPSL, University of Delaware, Newark, DE

    • Biotechnology, March 5, 1999, Computer and Information Sciences Department, University of Delaware, Newark, DE

    • Engineering approaches for optimal use of Genetically Engineered Organisms, March 17, 1999, Hercules, Wilmington, DE

    • Meeting to honor ex-student, Mike Betenbaugh's promotion to Full Professor, April 19, 1999, Johns Hopkins University, Baltimore, MD

    • Research Challenges in Bioinformatics and Biotechnology, November 3, 1999, Dow Chemical Co., Freeport, TX

    • Z. Chen, J-T Oh, P. Dhurjati, T. K. Van Dyk, R. A. LaRossa, S. L. Cooper, Synthesis and Toxicity Evaluation of Dendritic Biocides, 1998, Annual Meeting of the Society for Biomaterials, San Diego, CA

    • R. P. Wool, S. H. Kusefoglu, S. N. Khot, R. Zhao, G. Palmese, A. Boyd, C. Fisher, S. Bandypadhay, A. Paesano, P. Dhurjati, J. LaScala, G. Williams, K. Gibbons, M. Bryner, J. Rhinehart, C. Wang, and C. Soultoukis, Affordable Composites from Renewable Sources, 1998, American Chemical Society, Div. Polymer Chemistry, Boston, MA

    • November 4, 1998, University of Akron, Akron, OH

    • November 12, 1998, Purdue University, Laboratory of Renewable Resources Engineering (LORRE), West Lafayette, IN

    • Measures of Sustainability, November 20, 1998, Bryn Mawr University, Bryn Mawr, PA

    • Robert Brendel and Prasad Dhurjati, A Method for Analyzing Dynamics of Heat-Integrated Processes, November 1997, AICHE National Meeting, Los Angeles, CA

    • Kordon, A., Y. O. Fuentes, B. A. Ogunnaike, P. Dhurjati, An Intelligent Parallel Control System Structure for Plants with Multiple Operating Regimes, 1997, ESCAPE Conference, Computers and Chemical Engineering, S119-S124, Trondheim, Norway

    • March 12, 1997, Dow Chemical Co., Freeport, TX

    • March 18, 1997, AIChE Wilmington Section Meeting

    • April 29, 1997, Academy of Life Long Learning, Wilmington, DE

    • June 27, 1997, Laboratoire d'Automatique et de Genie des Procedes, University of Lyon, Lyon, France

    • June 30, 1997, French Petroleum Institute, Solaize, France

    • Applications of Knowledge-Based Systems for Fault Diagnosis, Supervision and Control, July 8, 1997, ENSIC, Nancy, France

    • Overview of Research In Intelligent Systems at UD, April/September 1997, Dow Chemical Co., Freeport, TX

    • D. J. Michaud, A. N. Beris, P. S. Dhurjati, Kinetic Behavior of a Vinyl-Ester Resin Within a Thick-Sectioned Composite, November 1996, AIChE National Meeting, Chicago, IL

    • R. J. Brendel, B. A. Ogunnaike, P. Dhurjati, A Nonlinear PI Controller Based on a Low-Order Empirical Process Model, November 1996, AIChE National Meeting, Chicago, IL

    • March 5, 1996, University of Queensland, Brisbane, Australia

    • March 19, 1996, University of Sydney, Sydney, Australia

    • March 14, 1996, Monash University, Melbourne, Australia

    • May 13, 1996, Flemish Institute of Technology, Mol, Belgium

    • May 14, 1996, University of Louvain-La-Neuve, Belgium

    • D. J. Michaud, A. N. Beris, P. S. Dhurjati, Curing Behavior of Thick Composites Manufactured by RTM, September 1995, Joint Composites Workshop on Manufacturing Science of Composites, Newark, DE

    • R. Larossa, D. A. Smulski, W. Majarian, R. Young, S. Belkin, A. C. Volmer, P. Dhurjati and T. K. Van Dyk, Luminescent Sensors Detecting Cellular Stress, March 1994, American Chemical Society, San Diego, CA

    • S. Rupani, K. Konstantinov, T. Van Dyk, W. Majarian and P. Dhurjati, On-line monitoring of recombinant Escherichia coli in batch and continuous cultures using a grpE promoter bioluminescence reporter gene system, March 1994, American Chemical Society, San Diego, CA

    • A. Kordon and P. Dhurjati, Model-Based Expert System for Improving Productivity of a Refinery Crude Unit, April 1994, AIChE Spring National Meeting, Atlanta, GA

    • Z.-Y. Yang, V. Pillai, A.N. Beris, and P. Dhurjati, Integrated Simulation, Optimization and Control of Autoclave Curing of Thick Laminate Composites, June 1994, CADCOMP94 Conference, Southampton, U.K.

    • P. Dhurjati, S. Rupani, V. Pillai, T. Van Dyk, R. LaRossa, Intelligent Supervision and Control of a Bioluminescent Culture for Development of an On-line Biosensor System, November 1994, Annual AIChE Meeting, San Francisco, CA

    • January 1994, National Environmental Engineering Research Institute, India

    • January 7, 1994, National Chemical Laboratory, India

    • January 10, 1994, Pasteur Institute, Paris, France

    • February 15, 1994, University of Minnesota, Minneapolis, MN

    • February 25, 1994, University of Pennsylvania, Philadelphia, PA

    • March 1994, University of Colorado, Boulder, CO

    • K. Konstantinov, T. Van Dyk, W. Majarian, P. Dhurjati, R. Larossa, On-line Monitoring of the Physiological State of Recombinant Cultures, April 1993, American Chemical Society, Denver, CO

    • T. Van Dyk, W. Majarian, K. Konstantinov, P. Dhurjati, R. Larossa, Pollutant Detection by Induction of a Heat Shock Promoter-lux Gene Fusion in Escherichia coli K12, May 1993, American Society of Microbiology National Meeting

    • Series of 10 seminars as a TOKTEN fellow of the United Nations Development Program, December 29, 1992 - January 26, 1993, National Environmental Engineering Research Institute, Nagpur, India

    • Expert Systems for Processing, May 18-20, 1993, Center for Composite Materials Workshop, Newark, DE

    • December 1993, Indian Institute of Science, Bangalore, India

    • Tokatlidis, K., P. Dhurjati, J. Millet, P. Béguin, and J. P. Aubert, High Activity of Inclusion Bodies formed in Escherichia coli overproducing Clostridium thermocellum Endoglucanase-D, April 1992, American Chemical Society National Meeting, San Francisco, CA

    • Klein, Jim and P. Dhurjati, Experimental Investigation of the In-vivo Kinetics of Inclusion Body Formation, April 1992, American Chemical Society National Meeting, San Francisco, CA

    • Tokatlidis, K., S. Salamitou, P. Béguin, P. Dhurjati and J. P. Aubert, Interaction of the Duplicated Segment carried by Clostridium themocellum Cellulases with Cellulosome Components, April 1992, American Chemical Society National Meeting, San Francisco, CA

    • Tokatlidis, K., S. Salamitou, P. Beguin, P. Dhurjati, J. Millet and J. - P. Aubert, Properties of the Duplicated Segment carried by Closturidium themocellum Cellulases, August 1992, Ninth International Biotechnology Symposium, Crystal City, VA

    • Overproduction of Recombinant Proteins: Specialized Ribosomes and Inclusion Bodies, February 11, 1992, University of Maryland, College Park, MD

    • Metabolic and Genetic Enhnacement of Microorganisms: Specialized Ribosomes and Inclusion Bodies, March 18, 1992, Dupont Environmental Biotechnology, Glasgow, DE

    • Tokatlidis, K., P. Dhurjati, J. Millet, P. Beguin and J-P. Aubert, Corps d'inclusion contentant une proteine recombinante active, mtg. on Conception, selection, production and analysis of proteins of a new generation, May 15-17, 1991, French Society for Microbiology and French Society of Biochemistry and Molecular Biology, Ecole Polytechnique, Palaiseau, Region Parisienne, France

    • Petti, T. F. and P. Dhurjati, Hydrogen Balance Advisory Control, May 29-30, 1991, IFAC Workshop on "Computer Software Structures integrating AI/KBS Systems in Process Control", Bergen, Norway

    • Leipold, R. J., R. W. Morgan and P. Dhurjati, Specialized Ribosomes and Feedback Regulation of rRNA Synthesis in E. coli, August 1991, American Chemical Society National Meeting, New York, NY

    • Leipold, R. J., R. W. Morgan and P. Dhurjati, Mathematical Model of Temperature-Sensitive Plasmid Replication, November 1991, AIChE National Meeting, Los Angeles, CA

    • Petti, T. F., and P. Dhurjati, Using Fuzzy Intervals for Resource Management, November 1991, AIChE National Meeting, Los Angeles, CA

    • Pillai, V., A. Beris and P. Dhurjati, Use of Local Criteria in Optimization of Batch Processes, November 1991, AIChE National Meeting, Los Angeles, CA

    • Dhurjati, P., K. Tokatlidis, P. Beguin, R. Tremel, R. Longin and J-P Aubert, Inclusion bodies formed by an endoglucanase and a xylanase cloned in E. coli, April 22-27, 1990, 199th National Meeting of the American Chemical Society, Boston, MA

    • Leipold, R. J., R. W. Morgan and P. Dhurjati, Specialized Ribosome System for the Overproduction of Proteins in E. coli, November 1990, AIChE National Meeting, Chicago, IL

    • Beyond FALCON: A Generalized Model-Based Approach to Automated Fault Diagnosis, April 6, 1990, Union Carbide Research Center, South Charleston, WV

    • Impact of Host-Plasmid Interactions on Foreign-Gene Expression and Product Activity, May 23, 1990, SANOFI (Elf Aquitaine) R & D Center, Labege, France

    • Petti, T. F. and P. Dhurjati, A Generalized Model-Based Approach to Automated Fault Diagnosis, March 18-22, 1989, AIChE Spring National Meeting, Orlando, FL

    • Varrin, R. D., and P. Dhurjati, Implementation of an Expert System for On-Line Fault Diagnosis in a Commercial Scale Chemical Process, Paper No. 21a, March 1988, AIChE Spring National Meeting, New Orleans, LA

    • Coppella, S. J., and P. Dhurjati, A Structured Mathematical Model for Recombinant Yeast Phenomena, September 25-30, 1988, 196th National Meeting of The American Chemical Society, Los Angeles, CA

    • Coppella, S. J., and P. Dhurjati, Production Kinetics of Human Epidermal Growth Factor in Recombinant Yeast, September 25-30, 1988, 196th National Meeting of The American Chemical Society, Los Angeles, CA

    • Betenbaugh, M. J. and P. Dhurjati, Independent Regulation of Recombinant Gene Expression and Plasmid Copy Number to Identify Metabolic Effects in E. coli, September 25-30, 1988, 196th National Meeting of the American Chemical Society, Los Angeles, CA

    • Fault Diagnosis in a Dynamic Chemical Process, February 2, 1988, Rhone-Poulenc Company, Lyon, France

    • Growth, Gene-Expression Kinetics and Plasmid Stability of Recombinant Microorganisms, February 25, 1988, University of Virginia, Charlottesville, VA

    • Host-Plasmid Interactions, Knowledge-Based Systems and their Relationship to Chemical Engineering, April 28, 1988, University of California, Santa Barbara, CA

    • Effects of Copy Number and Recombinant Gene Expression on Escherichia coli, May 13, 1988, Mycogen Corporation, San Diego, CA

    • Evaluation of Expression Systems for Recombinant Products, December 17, 1988, Indian Institute of Technology, New Delhi, India

    • Optimization of Recombinant Protein Product Using Sensitive Plasmids, December 19, 1988, Indian Institute of Technology, New Delhi, India

    • Fickelscherer, R., P. Dhurjati, D. Lamb and D. Chester, The FALCON Project: Application of An Expert System to Fault Diagnosis, Paper 82a, April 1987, AIChE Spring National Meeting, Houston, Houston, TX

    • Lamb, D. E., P. Dhurjati, D. Chester and R. Fickelscherer, Use of Mathematical Models in the Construction of Expert Systems for Fault Diagnosis in Chemical Plants, June 1987, IMACS International Symposium on AI, Expert Systems and Languages in Modeling and Simulation, Barcelona, Spain

    • Bischoff, K., and P. Dhurjati, Bioengineering, session on The New Technologies in Chemical Engineering, Paper 151c, November 1987, AIChE Annual Meeting, New York, NY

    • Growth, Gene-Expression Kinetics and Plasmid Stability of Recombinant Microorganisms, February 18, 1987, Lehigh University, Lehigh, PA

    • FALCON: An Expert System for Fault Diagnosis in a Commercial process Plant, March 10, 1987, NSF-AAAI Workshop on Artificial Intelligence in Process Engineering, Columbia University, New York, NY

    • FALCON: An Expert System for Fault Diagnosis in a Commercial Process Plant, May 20, 1987, The Dow Chemical Company, Midland, MI

    • Experience with the Development of an Expert System for Fault Diagnosis in a Commercial Scale Chemical Process, July 10, 1987, Foundations of Computer Aided Process Operations (FOCAPO) Conference, Salt Lake City, UT

    • FALCON: An Expert System for Fault Diagnosis in a Commercial Process Plant, July 20-24, 1987, Summer Session Course, Knowledge-Based Expert Systems in Process Engineering, MIT, Cambridge, MA

    • Process Trends Analysis and Diagnosis of Faults, November 2-3, 1987, First Annual Workshop, Laboratory for Intelligent Systems in Process Engineering, MIT, Cambridge, MA

    • Fickelscherer, R., P. Dhurjati, D. Lamb and D. Chester, Role of Dynamic Simulation in the Construction of Expert Systems for Process Fault Diagnosis, paper 51d, April 1986, AIChE National Meeting, New Orleans, LA

    • Galt, S. E., and P. Dhurjati, Control of Recombinant Escherichia coli containing Temperature-Sensitive Plasmid pOU 140, June 1986, American Control Conference (Winner of Award for Best Presentation in Applications of Advanced Process Control Section), Seattle, WA

    • DeBernardez, E., and P. Dhurjati, Effect of a Broad-Host Range Plasmid on the Growth Dynamics of E. coli and P. putida, July 1986, Engineering Foundation's Fifth International Conference on Biochemical Engineering, Henniker

    • Betenbaugh, M. J., and P. Dhurjati, Identifying Copy Number and Gene Expression Effects on the Kinetics of E. coli containing Temperature-Sensitive Plasmids, September 1986, 192nd American Chemical Society Meeting, Anaheim, CA

    • Coppella, S., C. M. Acheson and P. Dhurjati, Growth Kinetics, Plasmid Stability and Foreign Gene Expression in Saccharomyces cerevisiae, September 1986, 192nd American Chemical Society Meeting, Anaheim, CA

    • Galt, S. E., and P. Dhurjati, Mathematical Modeling of Recombinant E. coli with Temperature-Sensitive Plasmid pOU140, September 1986, 192nd American Chemical Society Meeting, Anaheim, CA

    • DeBernardez, E., and P. Dhurjati, Effect of a Broad-Host Range Plasmid on the Growth Dynamics of Three Gram-Negative Bacteria, September 1986, 192nd American Chemical Society Meeting, Anaheim, CA

    • Bree, M. A., P. Dhurjati, R. F. Geohagen and B. M. Robnett, Kinetics of Hybridoma Growth in Suspension Culture and Immunoglobulin Formation, September 1986, 192nd American Chemical Society Meeting, Anaheim, CA

    • DeBernardez, E., P. Dhurjati and D. E. Lamb, A Hybrid Heuristics and Mathematical Model Based Expert System to Diagnose Metabolic State of Cells, September 1986, 192nd American Chemical Society Meeting, Anaheim, CA

    • Kim, D., S. Kim and P. Dhurjati, Mathematical Modeling of the Mixed Culture Growth of Two Bacterial Populations with Opposite Substrate Preferences, September 1986, 192nd American Chemical Society Meeting, Anaheim, CA

    • Coppella, S. J., C. M. Acheson and P. Dhurjati, Measurement of Copy Number Using HPLC, September 1986, 192nd American Chemical Society Meeting, Anaheim, CA

    • DeBernardez, E., and P. Dhurjati, Prediction of the Dynamic Behavior of Temperature-Sensitive Recombinant Cells Using a Hybrid Heuristics and Mathematical Model Based Expert System, November 1986, AIChE Annual Meeting, Miami, FL

    • Betenbaugh, M. J., V. diPasquantonio and P. Dhurjati, Improvement of Product Yields by Temperature-Shifting E. coli Cultures Containing Plasmid pOU140, November 1986, AIChE Annual Meeting, Miami, FL

    • Lamb, D. E., P. Dhurjati, D. Chester and R. Fickelscherer, Use of Mathematical Models in the Construction of Expert Systems for Fault Diagnosis in Chemical Plants, November 1986, AIChE Annual Meeting, Miami, FL

    • Host-Plasmid Interactions in Recombinant Microorganisms, March 4, 1986, Columbia University, New York, NY

    • Growth, Gene-Expression Kinetics and Plasmid Stability of Recombinant Cells, April 18, 1986, Pfizer, Inc.

    • FALCON: An Expert System for Fault Diagnosis in Commercial Scale Chemical Plants, May 5, 1986, Lund Institute of Technology, Sweden

    • FALCON: An Expert System for Fault Diagnosis in a Commercial Scale Chemical Plant, July 21, 1986, Massachusetts Institute of Technology, Cambridge, MA

    • Growth, Gene-Expression Kinetics and Plasmid Stability of Recombinant Cells, October 27, 1986, OTSUKA Pharmaceuticals, Rockville, MD

    • Kinetics of Recombinant Microorganisms, November 17, 1986, Drexel University, Philadelphia, PA

    • Kinetics and Stability of Recombinant Microorganisms, December 2, 1986, Eastman Kodak Co.

    • FALCON: An Expert System for Fault Diagnosis in a Commercial Scale Chemical Plant, December 16, 1986, Air Products Company

    • Laffend, L. A., and P. Dhurjati, Growth Dynamics and Plasmid Segregation of Recombinant Bacillus subtilis, September 1985, 190th National American Chemical Society Meeting, Chicago, IL

    • Pih, N. P., and P. Dhurjati, Elucidation of Enzyme Control Mechanisms Using Macroscopic Measurements in a Mixed Substrate Fermentation System, September 1985, 190th National American Chemical Society Meeting, Chicago, IL

    • Betenbaugh, M. J., and P. Dhurjati, Growth Kinetics of Temperature-Sensitive Recombinant Cells, September 1985, 190th National American Chemical Society Meeting (Winner Of Peterson Award), Chicago, IL

    • Chester, D. L., D. E. Lamb, P. Dhurjati and J. Hale, An Academic/Industry Project to Develop an Expert System for Chemical Process Fault Detection, November 1985, Annual AIChE Meeting, Chicago, IL

    • Hopkins, D. J., M. J. Betenbaugh and P. Dhurjati, Environmental Effects on the Growth of A Recombinant Population of Escherichia coli containing Plasmid pKN 401, November 1985, Annual AIChE Meeting, Chicago, IL

    • Dhurjati, P., and M. S. Corley, Conflicting Microbial Growth Using a Computer-Coupled Fermenter, Session 72, Paper a, November 1984, Annual AIChE Meeting, San Francisco, CA

    • Mathematical Modeling of Microbial Systems, October 31, 1984, Dow Chemical Company, Midland, MI

    • Dhurjati, P., D. Ramkrishna, M. C. Flickinger and G. T. Tsao, A Computer Assisted Experimental Investigation of the Growth of Klebsiella pneumoniae in Multiple Substrate Systems, Session 88, Paper b, November 1982, Annual AIChE Meeting, Los Angeles, CA

    • Dhurjati, P., D. Ramkrishna, M.C. Flickinger & G. T. Tsao, Microbial Growth on Multiple Substrates. Models of Cells as Optimal Strategists, Session 105, Paper a, November 1980, Annual AIChE Meeting, Chicago, IL

    • I. Trezzani,, M. Nadri, C. Dorel, H. Hammouri, J. Lieto, P. Lejeune, R. Longin, P. Dhurjati, On-line control of fermentation processes using recombinant bioluminescent bacteria, September 2000, Eleventh International Symposium on Bioluminescence and Chemiluminescence

    • D. J. Michaud, P. S. Dhurjati, and Keith S. Decker, Intelligent Multi-Agent System for Information Management and Interpretation in Biotechnology Applications, November 12-17, 2000, AIChE Annual Meeting, Los Angeles, CA

    • April 1998, University of California, Riverside, Riverside, CA

    • Engineering of Genes, Metabolism and Reactors: The Bioinformatics Driven Renaissance, March 13, 2001, Pennsylvania State University, State College, PA

    • Engineering of Genes, Metabolism and Reactors: The Bioinformatics Driven Renaissance, May 21, 2001, Third Francophone Workshop on Biotechnology and Process Optimization, Casablanca, Morocco

    • A Scientific Foundation for the Biotechnics Debate, October 27, 2001, American Philosophical Association Conference, Newark, DE

    • Dennis Michaud (speaker), Keith Decker, and Prasad Dhurjati, A Bioinformatic Framework to Integrate Biological Knowledge with Methods for Analyzing Gene Expression Data, January 2001, 1st North American Symposium on Chemical Reaction Engineering, Houston, TX

    • Dennis J. Michaud and Prasad S. Dhurjati, A Dynamic Gene Expression Simulator to Examine Regulatory Networks and Evaluate Analysis Methods, November 2001, 2001 AIChE Annual Meeting, Reno, NV

    • Dennis J. Michaud, Prasad S. Dhurjati, and Antony N. Beris, Model-Based Global Optimization Using Robust Evolutionary Strategies, November 2001, 2001 AIChE Annual Meeting, Reno, NV

    • Dufour, P., Y. Toure, D. Michaud, and P. Dhurjati, Optimal trajectory determination and tracking of an autoclave curing process: a model based approach, 1999, Proceedings of ECC’99 European Control Conference, Karlsruhe, Germany

    • Sharad Bhartiya, Selwa Ben Amor, Prasad Dhurjati, Frank Doyle, Process Modeling, Control, And Monitoring For A Continuous Kamyr Digester, January 2003, International Symposium on Process Systems Engineering and Control (ISPSEC '03), IIT, Bombay, India

    • Pascal Dufour, Sharad Bhartiya, Thomas J. English, Edward P. Gatzke, Prasad S. Dhurjati and Francis J. Doyle III, Fault Detection in a Continuous Pulp Digester, June 8-9, 2001, Fourth IFAC Workshop on “On-Line Fault Detection and Supervision in the Chemical Process Industries, Seoul, South Korea

    • Agrawal, Vikas; Zhang, Chu; Shapiro, Allan D; and Dhurjati, Prasad, Computational Biology Approaches to Disease Resistance Signal Transduction, April 2002, 3rd Annual Arabidopsis Minisymposium, College Park, MD

    • Agrawal, Vikas; Zhang, Chu; Shapiro, Allan D; and Dhurjati Prasad S., Systems Biology Approaches to Understanding the Signaling Circuitry Underlying Arabidopsis thaliana Disease Resistance, November 2003, 4th International Conference on Bioinformatics, GeorgiaTech, Atlanta, GA

    All Publications

    1. Dhurjati, P., D. Ramkrishna, M. C. Flickinger and G. T. Tsao, "Cybernetic Modeling of Microbial Growth in Multiple Substrate Systems", Proc. Sec. World Cong. Chem. Eng., 16 (5), 252-255 (1981)

    2. Chester, D. L., D. E. Lamb and P. Dhurjati, "An Expert System Approach to On-Line- Alarm Analysis in Power and Process Plants", Computers in Engineering, 1, 345-351 (1984)

    3. Chester, D. L., D. E. Lamb and P. Dhurjati, "Rule-Based Computer Alarm Analysis in Chemical Process Plants", Microdelcon, 1, 22-29 (1984)

    4. Dhurjati, P., D. Ramkrishna, M. C. Flickinger and G. T. Tsao, "A Cybernetic View of Microbial Growth: Modeling of Cells as Optimal Strategists", Biotechnology and Bioengineering, 27, 1-9 (1985)

    5. Givler, R. M., P. Dhurjati and M. T. Klein, "A Model Compound Analysis of a Strategy for the Selective Microbial Pretreatment of Lignin", The Chemical Engineering Journal, 30, B37-B41 (1985)

    6. Lamb, D. E., P. Dhurjati and D. L. Chester, "Development of an Expert System for Fault Identification in a Commercial Scale Chemical Process", Proc. Sixth Int. Workshop on Expert Systems and Their Applications, Avignon, 2, 1371-1382 (1986)

    7. Hopkins, D. J., M. J. Betenbaugh and P. Dhurjati, "Effects of Dissolved Oxygen Shock on the Stability of Recombinant Escherichia coli Containing Plasmid pKN401", Biotechnology and Bioengineering, 29, 85-91 (1987)

    8. Pih, N. and P. Dhurjati, "Oscillatory Behavior of beta-galactosidase Enzyme Activity in Escherichia coli during Perturbed Batch Experiments", Biotechnology and Bioengineering, 29, 292-296 (1987)

    9. DiPasquantonio, V. M., M. J. Betenbaugh and P. Dhurjati, "Improvement of Product Yields by Temperature Shifting of Escherichia coli Cultures Containing Plasmid pOU140", Biotechnology and Bioengineering, 29, 513-519 (1987)

    10. DeBernardez, E. and P. Dhurjati, "Effect of a Broad-Host Range Plasmid on the Growth Dynamics of Escherichia coli and Pseudomonas putida", Biotechnology and Bioengineering, 29, 558-565 (1987)

    11. Coppella, S. J., C. M. Acheson and P. Dhurjati, "Measurement of Copy Number Using HPLC", Biotechnology and Bioengineering, 29, 646-647 (1987)

    12. Coppella, S. J. and P. Dhurjati, "Low Cost Computer-Coupled Fermentor Off-Gas Analysis via Quadrupole Mass Spectrometer", Biotechnology and Bioengineering, 29, 679-689 (1987)

    13. Kim, S. U. and P. Dhurjati, "Analysis of Two Interacting Bacterial Populations with Opposite Substrate Preferences", Biotechnology and Bioengineering, 29, 1015-1023 (1987)

    14. Betenbaugh, M. J., V. M. diPasquantonio and P. Dhurjati, "Growth Kinetics of Escherichia coli Containing Temperature-Sensitive Plasmid pOU140", Biotechnology and Bioengineering, 29, 1164-1172 (1987)

    15. Coppella, S. J., C. M. Acheson and P. Dhurjati, "Isolation of High Molecular Weight Nucleic Acids for Copy Number Analysis Using HPLC", Journal of Chromatography, 402, 189-199 (1987)

    16. Dhurjati, P., D. E. Lamb and D. C. Chester, "Experience in the Development of an Expert System for Fault Diagnosis in a Commercial Scale Chemical Process", in Foundations of Computer Aided Process Operations, (Elsevier Science Publishers, New York 1987)

    17. Venkatasubramanian, V. and P. Dhurjati, "An Object-Oriented Knowledge Base Representation for the Expert System FALCON", in Foundations of Computer Aided Process Operations, (Elsevier Science Publishers, New York 1987)

    18. Kim, S. U., D. Kim and P. Dhurjati, "Mathematical Model for the Mixed Culture Growth of Two Bacterial Populations with Opposite Substrate Preferences", Biotechnology and Bioengineering, 31, 144-159 (1988)

    19. Pih, N. P., E. DeBernardez and P. Dhurjati, "Elucidation of Enzyme Control Mechanisms Using Macroscopic Measurements in a Mixed Substrate Fermentation System", Biotechnology and Bioengineering, 31, 311-320 (1988)

    20. DeBernardez, E. D. and P. Dhurjati, "Host-Plasmid Interactions in Gram-Negative Bacteria Harboring Broad-Host Range Plasmids", BioProcess Engineering, 3, 141 (1988)

    21. Bree, M. A., P. Dhurjati, R. F. Geohagen and B. Robnett, "Kinetic Modeling of Hybridoma Cell Growth and Immunoglobulin Production in a Large Scale Suspension Culture", Biotechnology and Bioengineering, 32, 1067-1072 (1988)

    22. Mooney, D. J., D. Chester, D. Lamb and P. Dhurjati, "Design and Operation of the FALCON Interface", Proceedings of ISA, 88, 747-758 (1988)

    23. Coppella, S. J. and P. Dhurjati, "Mathematical Modeling of Cell Growth and Human Epidermal Growth Factor Production in Recombinant Yeast", in Proceedings of the ISMM International Symposium:, (ACTA Press, Anaheim 1988)

    24. Walker, C. C. and P. Dhurjati, "Use of Culture Fluorescence as a sensor for on-line discrimination between recombinant and host Escherichia coli", Biotechnology and Bioengineering, 33, 500-505 (1989)

    25. Betenbaugh, M. J., C. Beaty and P. Dhurjati, "Effects of Plasmid Amplification and Recombinant Gene Expression on the Growth Kinetics of Recombinant E. coli", Biotechnology and Bioengineering, 33, 1425-1436 (1989)

    26. Coppella, S. J. and P. Dhurjati, "Effect of Plasmid Size and Medium on Growth Kinetics and Plasmid Copy Number in Saccharomyces Cerevisiae", BioProcess Engineering, 4, 75-80 (1989)

    27. Coppella, S. J. and P. Dhurjati, "Alpha-Factor Directed Expression of the Human Epidermal Growth Factor in Saccharomyces Cerevisiae", Biotechnology and Bioengineering, 33, 976-983 (1989)

    28. Dhurjati, P. and R. J. Leipold, "Mathematical Modeling of Biological Systems", in Computer Control of Fermentation Processes, edited by Daniel R. Omstead (CRC Press, Boca Raton, FL 1989)

    29. Coppella, S. J. and P. Dhurjati, "A Detailed Analysis of Saccharomyces cerevisiae Growth Kinetics in Batch, Fed Batch, and Hollow Fiber Reactors", The Chemical Engineering Journal, 41, B27-B35 (1989)

    30. Coppella, S. J. and P. Dhurjati, "A Mathematical Description of Recombinant Yeast", Biotechnology and Bioengineering, 35, 356-374 (1990)

    31. Betenbaugh, M. J. and P. Dhurjati, "A Comparison of Mathematical Model Predictions to Experimental Measurements for Growth and Recombinant Protein Production in Induced Cultures of Escherichia coli", Biotechnology and Bioengineering, 36, 124-134 (1990)

    32. LaMarca, C., A. M. Lenhoff and P. Dhurjati, "Partitioning of Host and Recombinant Cells in Aqueous Two-Phase Polymer Systems", Biotechnology and Bioengineering, 36, 484-492 (1990)

    33. Petti, T. F., J. Klein and P. Dhurjati, "The Diagnostic Model Processor -Using Deep Knowledge for Process Fault Diagnosis", AIChE Journal, 36, 565-575 (1990)

    34. Betenbaugh, M. J. and P. Dhurjati, "Effects of Promoter Induction and Copy Number Amplification on Cloned Gene Expression and Growth of Recombinant Cell Cultures", Annals of the New York Academy of Sciences, 589, 111-120 (1990)

    35. Petti, T. F. and P. Dhurjati, "Object-Based Automated Fault Diagnosis", Chemical Engineering Communications, 102, 107-126 (1991)

    36. Tokatlidis, K., P. Dhurjati, J. Millet, P. Beguin and J-P. Aubert, "High Activity of Clostridium thermocellum endoglucanase D incorporated in inclusion bodies", FEBS Letters, 282,1, 205-208 (1991)

    37. Tokatlidis, K., S. Salamitou, P. BΘguin, P. Dhurjati, J-P. Aubert, "Interaction of the Duplicated Segment carried by Clostridium thermocellum cellulases with cellulose components", FEBS Letters, 291, 2, 185-188 (1991)

    38. Petti, T. F. and P. Dhurjati, "A Coupled Knowledge Based System Using Fuzzy Optimization for Advisory Control", AICHE J, 38, 1369-1378 (1992)

    39. Tokatlidis, K., S. Salamitou, T. Fujino, P. Béguin, P. Dhurjati, J. Millet, "Duplicated segment of clostridium thermocellum cellulases", in Protein Folding: In vivo and In Vitro, edited by Jeffrey L. Cleland (ACS Symposium Series 526 1993)

    40. Klein, J. H. and P. Dhurjati, "Experimental Investigation of the in vivo Kinetics of Inclusion Body Formation", in Protein Folding: In vivo and In Vitro, edited by Jeffrey L. Cleland (ACS Symposium Series 526 1993)

    41. Petti, T. F. and P. Dhurjati, "On-Line Hydrogen Resource Management in a Refinery Using Fuzzy Optimization", in On-Line Fault Detection and Supervision in the Chemical Process Industries, edited by P. Dhurjati and G. Stephanopoulos (Pergamon Press 1993)

    42. Pillai, V., A. Beris and P. Dhurjati, "Novel Method for the Optimal Control of Batch Processes", in On-Line Fault Detection and Supervision in the Chemical Process Industries, edited by P. Dhurjati and G. Stephanopoulos (Pergamon Press 1993)

    43. Gaertner, J. G. and P. Dhurjati, "Fractional Factorial Study of Hybridoma Behavior: I. Kinetics of Growth and Antibody Production", Biotechnology Progress, 9, 298-308 (1993)

    44. Gaertner, J. G. and P. Dhurjati, "Fractional Factorial Study of Hybridoma Behavior: II. Kinetics of Nutrient Uptake and Waste Production", Biotechnology Progress, 9, 309-316 (1993)

    45. Gaertner, J. G. and P. Dhurjati, "Specific cell adhesion as potential cause of interactions between hybridoma cells and reactor surfaces", Biotechnology Letters, 15(8), 803-808 (1993)

    46. Leipold, R. J. and P. Dhurjati, "Construction and Characterization of a Specialized Ribosome System for the Overproduction of Proteins in E. Coli", Biotechnology Progress, 8, 345-354 (1993)

    47. Kordon, A., R. Pitchumani, A. Beris, V. M. Karbhari and P. Dhurjati, "A Rheological Model for Particulate Ceramic Slurries at Low Temperatures", Scripta METTALURGICA et MATERIALIA, 29, 1095-1099 (1993)

    48. Leipold, R. J. and P. Dhurjati, "Review: Specialized Ribosomes in Escherichia coli", Biotechnology Progress, 9, 443-449 (1993)

    49. Konstantin, K. B., P. Dhurjati, T. Van dyk, W. Majarian, R. Larossa, "Real-time Compensation of the Inner Filter Effect in High-Density Bioluminescent Cultures", Biotechnology and Bioengineering, 42, 1190-1198 (1993)

    50. Tokatlidis, K., P. Dhurjati and P. Béguin, "Properties conferred on Clostridium thermocellum endoglucanase celC by grafting the duplicated segment of endoglucanase celD", Protein Engineering, 6, 947-952 (1993)

    51. Kordon, A. K., A. N. Beris, P. S. Dhurjati, B. Rossing and W. B. Johnson, "A knowledge base system architecture for a rapid ceramic performing process", Int. SAMPE Tech Conf., 25, 692-701 (1993)

    52. Pillai, V., P. Dhurjati and A. Beris, "Intelligent Control of an Autoclave Cure Process using an Expert System", Adv. Instrum. Control, 48, 48, 1431-1441 (1993)

    53. Leipold, R. J., C. E. Krewson and P. Dhurjati, "Mathematical Model of Temperature-Sensitive Plasmid Replication", Plasmid, 32, 131-167 (1994)

    54. Pillai, V., A. Beris and P. Dhurjati, "Implementation of model-based optimal temperature profiles for autoclave curing of composites using a knowledge-based system", Industrial and Engineering Chemistry Research, 33, 2443-2452 (1994)

    55. Van Dyk, Tina K., W. R. Majarian, K. B. Konstantinov, R. M. Young, P. Dhurjati and R. LaRossa, "Rapid and sensitive pollutant detection by induction of heat shock gene-bioluminescence gene fusions", Applied and Environmental Microbiology, 60, 1414-1420 (1994)

    56. Pitchumani, R., A. K. Kordon, A. N. Beris, V. M. Karbhari, P. S. Dhurjati, B. R. .Rossing and W. B. Johnson, "Thermofluid analysis and design of a low-temperature performing process", Metall. Mater. Trans. B, 25b, 761-771 (1994)

    57. Leipold, R. J., R. W. Morgan and P. Dhurjati, "Synthesis of non-translating or translating specialized ribosomes causes feedback regulation of ribosomal RNA synthesis in Escherichia coli", Biochemical and Biophysical Research Communications, 206, 393-400 (1995)

    58. Klein, J. and P. Dhurjati, "Protein Aggregation Kinetics in Escherichia coli Overexpressing a Salmonella typhimurium Che Y Mutant", Applied and Environmental Microbiology, 61, 1220-1225 (1995)

    59. Kordon, A. and P. Dhurjati, "An Expert System for Crude Unit Process Supervision", Proc.3rd IFAC Symp. on On-line Fault Detection & Supervision in the Chemic, 35-39 (1995)

    60. Pillai, V., A. Beris and P. Dhurjati, "Heuristics Guided Optimization of a Batch Autoclave Curing Process", Computers and Chemical Engineering, 20, 275-294 (1996)

    61. Rupani, S., Konstantin, K.B., M. B. Gu, P. Dhurjati, T. Van Dyk and R. LaRossa, "Characterization of the stress response of a bioluminescent biological sensor in batch and continuous cultures", Biotech. Progress, 12, 387-392 (1996)

    62. Gu, Man Bock, P. Dhurjati, T. Van Dyk and R. LaRossa, "A Novel Miniature Bioreactor for Sensing Toxicity using Recombinant Bioluminescent Escherichia coli cells", Biotech. Progress, 12, 393-397 (1996)

    63. Gu, Zhengrong, Harry Lam and P. Dhurjati, "Feature Correlation Method for Enhancing Fermentation Development: A Comparison of Quyadratic Regression with Artificial Neural Networds", Computers and Chemical Engineering, 20, S407-S412 (1996)

    64. Kordon, A. K., P. Dhurjati and B.J. Bockrath, "On-line Expert System for Odor Complaints in a Refinery", Computers and Chemical Engineering, 20, S1449-S1454 (1996)

    65. Brendel, R. J., B. A. Ogunnaike and P. Dhurjati, "A Nonlinear PI Controller Based on a Low-Order Empirical Process Model", Proc. IEEE on Computer-Aided Control System Design, 292-296 (1996)

    66. Pillai, V., A. Beris and P. Dhurjati, "Intelligent Curing of Thick Composites using a Knowledge Based System", Journal of Composite Materials, 31, 22-51 (1997)

    67. D. J. Michaud, A.N. Beris, P. Dhurjati, "Curing Behavior of Thick-Sectioned RTM Composites", Journal of Composite Materials, 32, 1273-1296 (1998)

    68. T. English, L. Kaiser, F. Doyle, P. Dhurjati, "Analysis of Post-upset Plant Data for Fault Detection", in On-Line Fault Detection and Supervision in the Chemical Process Industries, edited by P. Dhurjati and S. Cauvin (Pergamon Press, Oxford 1998)

    69. P. Dhurjati, "Reconciling Academic Approaches and Industrial Realities: Lessons from Fault Diagnosis Applications", in On-Line Fault Detection and Supervision in the Chemical Process Industries, edited by P. Dhurjati and S. Cauvin (Pergamon Press, Oxford 1998)

    70. Oh, J-T, T. K. Van Dyk, Y. Cajal, P. Dhurjati, M. Sasser, M. K. Jain, "Osmotic Stress in Viable Escherichia coli as the basis for Antibiotic Response by Polymyxnin B", Biochemical and Biophysical Research Communications, 246, 619-623 (1998)

    71. Oh, J-T, Y. Cajal, P. Dhurjati, T. K. Van Dyk, M. K. Jain, "Cecropins induce the hyperosmotic stress response in Escherichia coli", Biochimica et Biophysica Acta, 1415, 235-245 (1998)

    72. P. Dhurjati and Sylvie Cauvin, "On-line Fault Detection and Supervision in the Chemical Process Industries", Control Engineering Practice, 7, 7, 863-864 (1999)

    73. Kordon, A., P. Dhurjati, Y.O. Fuentes, B.A. Ogunnaike, "An Intelligent Parallel Control System Structure for Plants with Multiple Operating Regimes", Journal of Process Control, 453-460 (1999)

    74. Chen Z.C, Nora C. Beck-Tan, P. Dhurjati, T. K. van Dyk, R. A. LaRossa, S. L. Cooper, "Quaternary Ammonium Functionalized Poly (propylene imine) Dendrimers as Effective Antimicrobials: Structure-Activity Studies", Biomacromolecules, 1, 473-480 (2000) Full Text PDF

    75. Trezzani, I., Nadri, M., Hammouri, H., Lieto, J., Dorel, C., Lejeune, P., Dhurjati, P., Bellalou, J., Longin, R, "Quantification en ligne de al synthèse de molécules recombinantes par mesure de bioluminescence", Récents Progrès en Génie des Procédés, 15 (87), 147-155 (2001) Full Text PDF Not Available Online

    76. Michaud, D.J., A.N. Beris and P.S. Dhurjati, "Thick-sectioned RTM composite manufacturing: Part I. In situ cure model parameter identification and sensing", Journal of Composite Materials, 36 (10), 1175-1200 (2002) Full Text PDF

    77. Michaud, D.J., A.N. Beris and P.S. Dhurjati, "Thick-sectioned RTM composite manufacturing: Part II. Robust cure cycle optimization and control", Journal of Composite Materials, 36, 1201-1231 (2002) Full Text PDF

    78. Kauffman, K.J., E. M. Pridgen, F. J. Doyle, III, P. S. Dhurjati, A. S. Robinson, "Decreased protein expression and intermittent recoveries in BiP levels result from cellular stress during heterologous protein expression in Saccharomyces cerevisiae", Biotechnol. Prog., 18, 942-950 (2002) Full Text PDF

    79. Michaud, D. J., A. G. Marsh, and P. S. Dhurjati, "eXPatGen: Generating dynamic expression patterns for the systematic evaluation of analytical methods", Bioinformatics, 19(9), 1140-1146 (2003) www.che.udel.edu/eXPatGen/ Full Text PDF

    80. R. Lall, R. Mutharasan, Y. T. Shah, P. S. Dhurjati, "Decolorization of the dye Reactive Blue 19, using ozonation, ultrasound and ultrasound-enhanced ozonation", Water Environmental Research, 75, 171-179 (2003) Full Text PDF Not Available Online

    81. Trezzani, I., Nadri, M., Dorel, C., Lejeune, P., Bellalou, J., Lieto, J., Hammouri, H., Lieto, Longin, R., Dhurjati, P., "Monitoring of recombinant protein production using bioluminescence in a semi-automated fermentation process", Biotechnology Progress, 19, 1377-1382 (2003) Full Text PDF

    82. R. J. Brendel, B. A. Ogunnaike, P. S. Dhurjati, "Nonlinear PI Controllers Based on Low-Order Empirical Process Models", IEC Research, 42, 4668-4677 (2003) Full Text PDF

    83. R. Lall, G. Gao, P. Dhurjati, J. Edwards, "MRAD: Metabolic Reaction Analysis Database - An Entity-Relationship Approach", Journal of Molecular Microbiology and Biotechnology, 6 (1) (2003) http://capb.dbi.udel.edu/whisler/

    84. P. Dufour, S. Bhartiya, P. S. Dhurjati, F. J. Doyle III, "Neural Network-based Software Sensor: Training Set Design and Application to a Continuous Pulp Digester", Control Engineering Practice (2004), In Press

    85. V. Agrawal, C. Zhang, A.D. Shapiro and P.S. Dhurjati, "A Dynamic Mathematical Model to Clarify Signaling Circuitry Underlying Programmed Cell Death Control in Arabidopsis Disease Resistance", Biotechnology Progress, 20, 426-442 (2004) http://systemsbiology.udel.edu/ Full Text PDF

    86. P. Dufour, D.J. Michaud, Y. Toure, P.S. Dhurjati, "A Partial Differential Equation Model Predictive Control Strategy: Application to Autoclave Composite Processing", Computers and Chemical Engineering, 28, 545-556 (2004) Full Text PDF

    87. M. Nadri, I. Trezzani, H. Hammouri, P. Dhurjati, R. Longin, J. Lieto, "Modeling and Observer Design for Recombinant Escherichia coli strain", Bio Process Engineering, Submitted